Peptide ruins from Humans as Antivirals

A major breakthrough for a better future free of viruses



A collaboration between the Faculty of medicine in Ulm University and the Faculty of Pharmacy and Biotechnology in the German University in Cairo to give their first workshop under the title “Unearthing the human peptidome” will take place tomorrow Monday the 4th of December, at the German University in Cairo to discuss the new breakthrough of using “Peptide ruins from humans as antivirals”.This collaboration is funded by the German Academic Exchange Service (DAAD)  and the German Federal Ministry of Education and Research (BMBF).

The project began by discovering that the hemodialysate (which is the fluid and waste products removed from the blood to correct electrolyte imbalances in case of kidney failure) contains humans peptides that could be further fractionated into original active peptides of antiviral effect without cost all that is needed is to spare the wasted fluid post-dialysis to be recovered.

The faculty of Medicine in Ulm is currently working on the discovery of antivirals from this technique to block the infection and entry of viruses like HIV, HSV, HCMV and HCV under the supervision of Prof. Dr. Jan Münch,  head of the Institute of Molecular Virology Ulm University Hospital. While on the other hand, the German University in Cairo is working on how to optimize these active peptides into synthetic peptides of better structure, activity, selectivity, and stability under the supervision of Prof.Dr.Ashraf Abadi Professor of Pharmaceutical Chemistry.

According to Dr.Ashraf Abadi “The most important finding discovered by Monica Maged and Amal Ali respectively was the ability to optimize the potency of one of the peptides against the entry of HIV virus into human cells by 16,000x folds and another one against HCMV virus by 30x folds.”

Another finding for extracting peptides was “discovering antimicrobial peptides by digesting abundant proteins in our bodies” conducted byTriveena Maher under the supervision of Dr.Nermin Salah and Dr.Mohamed Abdel-Halim ,This technique tackles the ability to take out a human peptidase (which is the enzyme responsible for breaking down protein bonds) and use it to break a human protein, such as serum albumin or hemoglobin into smaller peptides repurposed to different use.

This major breakthrough remains one of a kind in Egypt and the Middle East, a new perspective in the pharmaceutical biotechnology that leaves us with a hope for a better future free of viruses.

 

No registration is required to attend.